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Cardiac conduction effects of desyrel trazodone hydrochloride in the anesthetized dog are qualitatively dissimilar and quantitatively less pronounced than those seen with tricyclic antidepressants.

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In vitro drug metabolism studies suggest that there is a potential for drug interactions when trazodone is given with CYP3A4 inhibitorsRitonavira potent CYP3A4 inhibitorincreased the C maxAUCand elimination half-lifeand decreased clearance of trazodone after administration of ritonavir twice daily for 2 daysAdverse effects including nauseahypotensionand syncope were observed when ritonavir and trazodone were co-administeredIt is likely that ketoconazoleindinavirand other CYP3A4 inhibitors such as itraconazole or nefazodone may lead to substantial increases in trazodone plasma concentrationswith the potential for adverse effectsIf trazodone is used with a potent CYP3A4 inhibitora lower dose of trazodone should be considered.

It is important to continue taking this medication as prescribed even if you feel wellTo help you remembertake it at the same time(seach dayDo not stop taking this medication without consulting your doctorAnxietyagitationand trouble sleeping can occur if the drug is suddenly stopped.

Hypotensionincluding orthostatic hypotension and syncopehas been reported to occur in patients receiving DesyrelConcomitant administration of antihypertensive therapy with Desyrel may require a reduction in the dose of the antihypertensive drug.

Because the frequency of adverse drug effects is affected by diverse factorsegdrug dosemethod of detectionphysician judgmentdisease under treatmentetca single meaningful estimate of adverse event incidence is difficult to obtainThis problem is illustrated by the variation in adverse event incidence observed and reported from the inpatients and outpatients treated with DesyrelIt is impossible to determine precisely what accountsfor the differences observed.

Lung problems or other complications in the baby may arise if you are taking this medication while pregnantThere is risk of depression relapse if you stop taking your antidepressantTell your doctor right away if you become pregnant while taking TrazodoneDo not start or stop taking this medicine during pregnancy without consulting your doctor.

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